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The U.S. is trying to seal a new NAFTA deal by the end of this week, but there are still several hurdles. David Greene talks to John Manley, a former Canadian economic minister, about what's at stake.

The Trump administration hopes the sanctions will force Iran to negotiate a new nuclear deal. But analysts point out there are overt and covert activities to avoid the penalties.

Julian Assange, founder of Wikileaks, was arrested in London Thursday. He is charged with a single count of conspiracy related to the release of secret U.S. government documents in 2010.

President Trump's nominee to be ambassador to Saudi Arabia was approved by the Senate Wednesday. NPR's Ailsa Chang talks with Brian Katulis of the Center for American Progress about the new ambassador.

The U.S.-backed coalition says it aims to oust Iranian-sponsored Houthi rebels, but aid groups warn of potentially high civilian casualties.

NPR's Ailsa Chang speaks with Melissa Hanham, weapons of mass destruction expert, about the timing and global impact of the U.S. pulling out of the nuclear non-proliferation treaty with Russia.

NPR's Mary Louise Kelly talks with Joyce White Vance, former U.S. attorney in Alabama, about why she chose not to pursue an ICE raid similar to the one in Mississippi during the Obama administration.

There's another COVID-19 vaccine. This one was developed by the U.S. biotech company Novavax. It's almost 90% effective against the disease, but isn't as effective against the South African variant

Cubans are fleeing because of a steep economic downturn. Immigration is a big issue as leaders meet at this week's Summit of the Americas — but communist-controlled Cuba isn't invited.

Former president Donald Trump spoke in Dayton, Ohio, on March 16, 2024, for a rally for Bernie Moreno, one of three candidates in the U.S. Senate Republican primary.