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The prime-time address is a chance for the president to tout his record ahead of this year's midterm elections. But it comes at a moment when Trump has seen his agenda complicated on multiple fronts.

Biden and Trump will hold their first presidential debate tonight. Scientists think understanding how the brain removes waste and toxins may help treat a broad range of disorders.

The Rev. Dr. Daniel P. Matthews, the rector at Trinity Church on Wall Street during the Sept. 11 terrorist attacks, discusses his experience and the ways Lower Manhattan has changed since.

Early voting in Northeast Ohio continued to draw long lines at county boards of elections over the weekend, Joe Biden will spend part of his final campaign push in Cleveland Monday, Ohio reported around 3,300 COVID-19 cases on Sunday, and more stories.

Marie Yovanovitch was recalled from her post in May after criticism from some Republicans, including the president's eldest son, that she was not supportive of the administration's policies.

NPR's Mary Louise Kelly speaks with H. Jon Benjamin about his new book, Failure Is An Option. The memoir urges us to let go of the constant grind towards success.

Attorney Benjamin Crump tweets the news of Jacob Blake's condition Tuesday — and adds he is praying it is not permanent. Blake was shot in the back by police in Wisconsin on Sunday.

While a valiant endeavor, the Metropolitan Opera's new series of steaming concerts can't seem to shake off opera's fusty, aristocratic traditions.

NPR's Ari Shapiro talks with Nick Clegg of Facebook about the company's decision to refer questions on the suspension of former President Donald Trump's account to its independent Oversight Board.

The number of families struggling to afford food has skyrocketed since the start of the crisis. One family in Champaign, Ill., used to volunteer at a food pantry — now they depend on it.