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Exit polls in Ukraine's second attempt at a presidential election indicate a landslide victory for opposition leader Victor Yushchenko. With a high voter turnout estimated at 78 percent, Yushchenko captured more than 60 percent of the ballots cast. Hear NPR's Jacki Lyden and NPR's Lawrence Sheets.

Pharmaceutical company Pfizer announces that its popular painkiller Celebrex may increase the risk of cardiovascular problems. New study results indicate more than double the risk of major heart problems, but another study failed to corroborate the finding. NPR's Richard Knox reports.

Amid mass protests in Kiev, Ukraine's Supreme Court is reviewing that country's disputed presidential election. Petro Koshukov, co-founder of "Znaio," a voter education project in Ukraine, talks with NPR's Steve Inskeep about the mood of Ukrainian protesters and how the disputed election may be resolved.

Shoppers across the country throng stores in search of bargains at the traditional start to the holiday shopping season, as retailers hope for a strong end to the year. Analysts predict shoppers will spend slightly more than last year between now and the end of next month. NPR's Jackie Northam reports.

Iraq's Shiite population seeks new political power after years of oppression. There are more Shia living in Iraq than Sunnis or Kurds. But there are fissures between Islamic and secular Shia, and it is unclear whether cleric Muqtada al-Sadr will participate in the elections. NPR's Emily Harris reports.

A federal judge in New York rules that a portion of the USA Patriot Act is unconstitutional. The judge said the FBI's power to demand records from companies does not provide sufficient oversight or controls. NPR's Larry Abramson reports.

The Supreme Court announces it will hear arguments on posting the Ten Commandments on public property. Such cases have been making their way through courts in many states, and have resulted in conflicting rulings. Hear NPR's Michele Norris and NPR's Nina Totenberg.

Hundreds of tons of explosives disappear in Iraq. NPR's Alex Chadwick speaks to Los Angeles Times correspondent Monty Morin in Baghdad about that development and insurgent leader Abu Musab al-Zarqawi's claim that his group is behind the assassination of nearly 50 Iraqi soldiers.

Congress is considering changes to the way the Food and Drug Administration handles drug safety. An FDA scientist testified that superiors pressed him to soften conclusions on the safety of profitable drugs... and that at least five drugs on the market have major problems. Hear NPR's Joanne Silberner.

The fighting in Fallujah rouses strong -- but mixed -- emotions among Iraqis. It is also triggering further violence in several parts of the country. Insurgents reportedly mounted the third major attack on the Iraqi police within four days, storming their bases in Baquoba, 40 miles from the capital. Hear NPR's Philip Reeves.