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Sickle cell disease is an affliction of the red blood cells often diagnosed early in childhood. While the disease was once more deadly, today with medications and frequent doctor visits those who inherit the malady can manage it and live longer lives. However the transition period between childhood and adulthood can be a challenge for patients to be diligent in managing the disease.

The Cleveland Foundation has announced the winners of the 83rd annual Anisfield-Wolf Book Awards. In 19-35, Cleveland poet and philanthropist Edith Anisfield-Wolf established the award as a way to honor literature that explores issues of racism and diversity. Awards manager Karen Long shares thoughts on this year's winners. Poetry:Shane McCrae, In the Language of My Captor

No “Hamilton” tickets? There’s still hope. Single tickets for Lin-Manuel Miranda’s smash Broadway musical, which comes to Playhouse Square this summer, go on sale Friday April 13.

Family drama has long been fodder for great storytelling. It has everything you need: love, loss, compassion and conflict. The 2016 Tony Award-winning play "The Humans" stakes its own ground in this territory by telling the contemporary tale of the Blake family. Erik and Deirdre Blake arrive for the Thanksgiving holiday at their daughter's New York City apartment, and from there the play unfolds in real time.

For the fourth straight year, the U.S. high school graduation rate has improved — reaching an all-time high of 82 percent in the 2013-2014 school year, the Department of Education announced Tuesday.

Among several reforms, Judge Donald McCullin ordered that all arrest warrants issued in Ferguson before 2015 be withdrawn.

The mayor of Akron and Summit County prosecutor are asking Cuyahoga County investigate allegations surrounding former Akron Police Chief James Nice. Mayor Dan Horrigan requested Nice’s resignation over the weekend, citing “conduct unbecoming of an officer.”

By making fun of her anxieties onstage as a stand-up comic, Aparna Nancherla is making a difference as she challenges mental health stigmas. This week the acclaimed comedian, who has depression, comes to town for Acting Out Cleveland, a four-day arts fest for mental health and addiction awareness. She recently appeared onStudio 360with Kurt Andersen and Conanwith Conan O'Brien.

Award-winning author and Shaker Heights native Martha Conway's new novel - The Underground River - takes inspiration from a true-life tragedy. While researching the Antebellum period before the Civil War, Conway discovered the story of the Steamboat Moselle, one of the fastest riverboats of its time. On April 25, 1838, disaster struck the Moselle on the Ohio River near Cincinnati. "The captain was racing another steamboat, the Tribune. He overstocked the boilers and it exploded," Conway said.

The U.S. Food and Drug Administration warns of a shortage of a certain type of blood pressure medication, after contaminants were found that may be linked to cancer. The class of blood pressure drugs known as angiotensin II receptor blockers, or ARBs, have been recalled because of manufacturing impurities, which the FDA describes as “probable human carcinogens.” The recalled drugs include several brands of generic valsartan, losartan, and irbesartan.